NREL Postdoctoral Researcher – Systems Biology in Golden, Colorado

Posting Title

Postdoctoral Researcher – Systems Biology

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Location

CO - Golden

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Position Type

Postdoc (Fixed Term)

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Hours Per Week

40

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Job Summary

The National Renewable Energy Laboratory (NREL) is a leader in the U.S. Department of Energy’s effort to secure an energy future that is both environmentally and economically sustainable. With locations in Golden, Boulder and Washington D.C., NREL is the primary laboratory for research, development and deployment of renewable energy technologies in the United States. The NREL mission is to develop renewable energy and energy efficient technologies and practices, advance related science and engineering, and transfer knowledge and innovation to address the nation’s energy and environmental goals.

The Biosciences Center conducts leading-edge interdisciplinary research to reduce the cost of biomass to fuels and biochemicals. A lot of this effort is focused on improving microorganisms to efficiently produce fuels and value-added chemicals. These improvements may come about with modified/improved metabolic pathways, improved metabolic enzymes, and more robust microorganisms. Additionally, new research efforts geared towards cell free production of this biochemicals require engineering of novel/non-natural metabolic pathways or the use of hybrid approaches.

We have an immediate opening for a full time Postdoctoral Researcher in systems biology. The successful applicant for this position will be a key member of an interdisciplinary team involved in all aspects of metabolic pathway and model reconstruction, strain development, and characterization. Exceptional science skills, experience, and demonstrated teamwork are required for this position. The assignment is nominally for one year with possible renewal.

This Postdoctoral Researcher will be responsible for developing or refining metabolic models for several microorganisms using available toolboxes such as COBRA, RAVEN or other tools developed in house. Additionally, the successful candidate will need to use or develop new computational techniques for redesigning metabolic networks for in vivo or in vitro applications. The candidate will also work towards finding de novo pathways for the production of specialty chemicals by taking advantage of enzyme promiscuity or enzymatic/chemical catalytic hybrid routes to access new intermediate/product spaces.

The individual in this position will be a key contributor and member of a diverse team of researchers. Responsibilities of this position also include the preparation of technical reports, journal articles, and presentations.

Desired Qualifications:

  • A recent PhD graduate in biophysics, chemical engineering, mathematics, or a closely related field within the last three years.

  • Experience with metabolic models and applyinig simulation tools to predict growth, effects of pathway deletion, and insertion

  • Experience analyzing fluxomic data sets

  • Experience in kinetic modeling with thermodynamic constraints

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Required Education, Experience, and Skills

Must be a recent PhD graduate within the last three years.

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Preferred Qualifications

Training or experience in:

  • Metabolic model development

  • Development of simulation toolboxes for kinetic modeling

  • De novo metabolic pathway prediction

  • Metabolic control analysis

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Submission Guidelines

Please note that in order to be considered an applicant for any position at NREL you must submit an application form for each position for which you believe you are qualified. Applications are not kept on file for future positions. Please include a cover letter and resume with each position application.

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EEO Policy

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The National Renewable Energy Laboratory (NREL) is a leader in the U.S. Department of Energy’s effort to secure an environmentally and economically sustainable energy future. With locations in Golden and Boulder, Colorado, and a satellite office in Washington, D.C., NREL is the primary laboratory for research, development, and deployment of renewable energy technologies in the United States.

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