Colorado Energy Jobs

Colorado Jobs

Job Information

Zoetis SCIENTIST/SR SCIENTIST- PROTEIN DESIGN (Fixed Term: 3.5 Year in Fort Collins, Colorado

Zoetis is seeking a talented and experienced protein engineer to contribute toour efforts in Global Therapeutics Research at Zoetis. This individual willpartner with project teams to build a basic understanding of diseasetargets, pathways, and therapeutic mechanisms of action throughstructure-based protein design, engineering, and computational modeling.The successful candidate should have knowledge of antibodies and/or proteininteractions and relevant experience with high resolution structuredetermination methods such as Cryo EM, in silico protein homology models,protein docking, and epitope mapping. Experience with and understanding ofpeptide design, protein design and engineering, molecular biology, andprotein characterization is preferred. Excellent communication,organizational and interpersonal skills are essential. Some travel required.Please note: This position is for a fixed term of 3.5 years.POSITION RESPONSIBILITIES:Protein and antibody in silico design and structural mappingEpitope mapping and immunogen designDevelop understanding of protein-protein interactions and target inhibitionAntibody optimization and affinity maturation using rational design techniquesCollaborate across multiple scientific disciplines to understand mechanisticbiologyWork closely with team leads to identify potential therapeutic substrateDirectly communicate with external partners for collaborations andoutsourcing.EDUCATION AND EXPERIENCE:Educational background: Ph.D. in engineering, structural biology,computational biology, molecular or cellular biology, immunology,biochemistry, or related field; or M.S. with at least 5 years relevantexperienTraining or experience in biological sciences focusing on protein engineeringand protein modeling with an emphasis on understanding epitopes andprotein-protein interactions.Expertise in single particle cryo-EM processes (including sample/gridpreparation and screening, data collection and processing,three-dimensional reconstruction and model building).Expertise in protein modeling techniques including homology modeling,epitope/paratope mapping, in silico protein optimization, and immunogendesign.Exposure to affinity maturation and antibody optimization approaches(phage, yeast, mammalian, or mRNA display; rational designtechniques) preferred.Some experience with molecular biology and molecular cloning techniquesincluding subcloning, site-directed mutagenesis, PCR and DNA manipulationis desired.Exposure to protein expression and isolation (mammalian and bacterialsystems), affinity chromatography, protein biochemistry and proteinquantification (SDS-PAGE protein gels, Westerns, analytical SEC,ELISAs, SPR) iFamiliarity with Linux OS (install, configure and maintain) is a strong plus.Self-starter, able to prioritize work and work efficiently, designexperiments with minimal supervision, and able work across teams remotelyand face-to-face.Experience interacting with CROs or external partnershipsExcellent verbal/written communication, organizational and interpersonalskillsComputer skills required: Microsoft Word, Excel, Outlook, BLAST,Vector NTI or equivalent, protein modeling software (MOE, Rosetta, etc.)ADDITIONAL INFORMATION:Work environment:The placement of this position will be primarily in Boulder, CO, withlaboratories located in Fort Collins, CO. This person will be expected totravel to Fort Collins, CO on a regular basis to interact with projectteams. Occasional travel to RandD headquarters in Kalamazoo, MI may also berequeThe person filling this position may work partly in a laboratory setting.There may be exposure to animal pathogens and chemicals. There may be handlingof, and/or exposure to animal tissue and zoonotic organismsZoetis is committed to equal opportunity in the terms and conditions ofemployment for all employees and job applicants without regard to race,color, religion, sex, sexual orientation, age, gender identity orgender expression, national origin, disability or veteran status or anyoth

DirectEmployers