Colorado State University Research Scientist I- Hoover/Mathiason Lab in Fort Collins, Colorado

Posting Detail Information

Working Title Research Scientist I- Hoover/Mathiason Lab

Research Professional Position Yes

Posting Number 201800772AP

Position Type Admin Professional/ Research Professional

Number of Vacancies

Work Hours/Week 40

Proposed Annual Salary Range $60,000 - $70,000

Desired Start Date

Position End Date (if temporary)

Open Posting Date 08/24/2018

Open Until Filled Yes

To ensure full consideration, applications must be received by 11:59pm (MT) on 09/16/2018

Description of Work Unit

The Microbiology, Immunology and Pathology (MIP) Department is comprised of over 400 individuals who share a common passion for solving some of the most important human and animal health problems today. Research programs include those related to mycobacteria, retroviruses, prions, and arthropod-borne infectious diseases, as well as the diagnostic investigation of naturally-occurring animal diseases. A leader in education, MIP provides the only microbiology undergraduate degree program in Colorado, a graduate program that provides training in a number of cutting-edge disciplines, and several specialized veterinary residency training programs.

Position Summary

Within the CSU Prion Research Center, Department of Microbiology, Immunology and Pathology, the Hoover and Mathiason laboratories require a specifically experienced research scientist to conduct research on prion and other protein misfolding diseases. This research employs a blend of protein chemistry, molecular biology, and several other laboratory methods to investigate the detection, transmission, and pathogenesis of the prion disease chronic wasting disease [CWD] of cervids (deer and elk), as well as other protein misfolding neurologic diseases (e.g. Alzheimer’s and Parkinson’s diseases, traumatic brain injury). The position will report to either or both Professor Dr. Edward Hoover and Professor Dr. Candace Mathiason and will be focused primarily on new methods in vitro to detect misfolded protein seeds that are associated with prion and other protein misfolding disorders, and commonly also involves studies on biologic samples from animals and humans. The Research Scientist will conduct and conceive of experiments independently, interface with the combined laboratories’ manager and multiple laboratory personnel of varying seniority, supervise undergraduate and some graduate level students, and work closely with members of the Hoover and Mathiason laboratory teams. Specific experience with prion or prion-like protein misfolding diseases, biochemistry, cell biology, pathobiology, and/or other infectious diseases at the basic science level are pertinent. Ability to work both independently and as a contributor to project teams, and supervise junior scientists in training are essential for this position.

Required Job Qualifications

Applicants must hold a PhD degree and/or DVM/PhD degrees in microbiology, biochemistry (or closely related field) and 3 years postdoctoral laboratory experience including infectious disease work at BSL2 level. The candidate must have a strong work ethic, excellent organizational and communication skills, knowledge of standard computer applications, and must have the ability to work productively as a member of a laboratory team yet also independently as circumstances require.

Preferred Job Qualifications

Desirable elements for the successful candidate include but are not limited to:

  • Experience with prion protein amplification assays [e.g. real-time induced conversion (RT-QuIC); serial protein misfolding cyclic amplification (sPMCA)], immunohistochemistry, and western blotting, DNA/RNA purification, and QPCR.

  • Experience working with transgenic mice and other animal species or animal tissues.

  • Experience with analyzing data, generating reports and manuscript writing is desirable

  • Excellent precision, organization, and record keeping skills.

  • Experience with prion or other protein seeding amplification assays, immunohistochemistry, and other common laboratory methods

Diversity Statement

Reflecting departmental and institutional values, candidates are expected to have the ability to advance the Department’s commitment to diversity and inclusion.

Essential Duties

Job Duty Category Research and Analysis


Independently conduct scientific research. This will involve: 1. Design, plan and execute studies involving transmission and pathogenesis of CWD in the native cervid host. Sample collection, preparation and storage of biological samples. Analyze data from these studies. Prepare figures summarizing experimental and analysis results. 2. Present the results of studies in local, regional, and national venues. 3. Maintain BSL2 animal and laboratory records, provide written and oral updates on ongoing and completed studies. 4. Generating and maintaining animal and laboratory SOPs. 5. Provide leadership through expertise contribution, attending investigator meetings and consultation on other projects as appropriate. 6. Experimental design: Formulate hypotheses, determine proper controls and experimental protocols. 7. Experimental execution and optimization: Conduct experiments, modifying and optimizing protocols as necessary. 8. Data interpretation and analysis: analyze results of experiments and interpret in the context of the hypothesis and relevant literature.

Percentage Of Time 70

Essential Duties

Job Duty Category Laboratory and research operations


As may be needed, in conjunction with CSU Laboratory Animal Resources (LAR), assist with oversight to maintain well-being of animals used in studies

Percentage Of Time 5

Essential Duties

Job Duty Category Manuscript / grant writing and supervision


  1. Prepare manuscripts and grant applications. Assist in supervising undergraduate researchers and research assistants.
  2. Analyze and interpret data, communicate results in professional presentations, metings, and publications.

Percentage Of Time 25

Application Details

Special Instructions to Applicants

For full consideration, please apply by 9/16/18, 11:59 pm (MT). Interested applicants must submit a cover letter which addresses how professional experiences align with identified required and preferred qualifications of the position, a current CV, and contact information for 3 professional references. References will not be contacted without prior notification of candidates

Conditions of Employment Pre-employment Criminal Background Check (required for new hires), Use, Handling, or Exposure to hazardous materials

Search Contact Dr. Edward Hoover,

EEO Statement

Colorado State University is committed to providing an environment that is free from discrimination and harassment based on race, age, creed, color, religion, national origin or ancestry, sex, gender, disability, veteran status, genetic information, sexual orientation, gender identity or expression, or pregnancy and will not discharge or in any other manner discriminate against employees or applicants because they have inquired about, discussed, or disclosed their own pay or the pay of another employee or applicant. Colorado State University is an equal opportunity/equal access/affirmative action employer fully committed to achieving a diverse workforce and complies with all Federal and Colorado State laws, regulations, and executive orders regarding non-discrimination and affirmative action. The Office of Equal Opportunity is located in 101 Student Services.

The Title IX Coordinator is the Executive Director of the Office of Support and Safety Assessment, 123 Student Services Building, Fort Collins, CO 80523 -2026, (970) 491-7407.

The Section 504 and ADA Coordinator is the Associate Vice President for Human Capital, Office of Equal Opportunity, 101 Student Services Building, Fort Collins, CO 80523-0160, (970) 491-5836.

Background Check Policy Statement

Colorado State University (CSU) strives to provide a safe study, work, and living environment for its faculty, staff, volunteers and students. To support this environment and comply with applicable laws and regulations, CSU conducts background checks. The type of background check conducted varies by position and can include, but is not limited to, criminal (felony and misdemeanor) history, sex offender registry, motor vehicle history, financial history, and/or education verification. Background checks will be conducted when required by law or contract and when, in the discretion of the university, it is reasonable and prudent to do so.

References Requested

References Requested

Minimum Requested 3

Maximum Requested 3

Supplemental Questions

Required fields are indicated with an asterisk (*).

Applicant Documents

Required Documents

  • Curriculum Vitae

  • Cover Letter

Optional Documents