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Colorado State University Research Associate I - Drug Discovery and Development Shared Resource in Fort Collins, Colorado

Working Title Research Associate I - Drug Discovery and Development Shared Resource

Position Location Fort Collins, CO

Research Professional Position Yes

Posting Number 202000634AP

Position Type Admin Professional/ Research Professional

Number of Vacancies

Work Hours/Week 40

Proposed Annual Salary Range 40000 - 50000

Desired Start Date

Position End Date (if temporary)

To ensure full consideration, applications must be received by 11:59pm (MT) on 08/30/2020

Description of Work Unit

The Department of Clinical Sciences mission is to assure the health and productivity of animals to meet societal needs through high quality educational programs for professional veterinary medical students, graduate veterinarians, and the public through a faculty and veterinary medical center of excellence, and to advance and disseminate comparative biomedical knowledge in an environment of interdisciplinary collaboration.

Position Summary

The Pharmacology Shared Resource has been operating continuously since 1999 as a component of the CU Cancer Center and moved to CSU with me in 2007. This Shared Resource carries out dose finding toxicity and drug analysis studies for investigators who are members at the CU Cancer Center and has also played a prominent role in advancing the careers of veterinary clinical investigators at CSU. This position will play a role in organizing and carrying out functions in the revised version of this Shared Resource that has been newly re-named as the Drug Discovery and Development Shared Resource (DDDSR).

If you move forward in the search process, you will be asked to demonstrate your ability to perform biochemical and analytical calculations.

Required Job Qualifications

• A bachelor’s degree in biology, chemistry, biochemistry or a related field • Demonstrated computational skills • Ability to use spreadsheets and organize data • Willingness to work with rodents for toxicity and dosing studies

Preferred Job Qualifications

• Experience in analytical chemistry • Experience in enzymology and drug metabolism • Animal handling and drug dosing • Experience in pharmacokinetic and data modeling

Diversity Statement

Personal or professional commitment to diversity and inclusion as demonstrated by persistent effort, active planning, allocation of resources and/or accountability for diversity and inclusion outcomes.

Essential Duties

Job Duty Category Drug Dosing Studies in Rodents

Duty/Responsibility

  1. Animals are dosed with novel agents by various dose routes and either monitored for toxicity or efficacy or are euthanized for tissue collection.
  2. Determining toxicity of novel compounds, measuring the PK of novel agents or to test how well a novel agent works in treating cancer.

Percentage Of Time 10

Job Duty Category In Vivo Pharmacology Studies

Duty/Responsibility

  1. Incubation of novel agents with microsomes, liver slices or isolated hepatocytes and collecting samples for analysis of parent drug and/or metabolites. This may also include studies measuring serum stability, benchtop stability, PAMPA membrane permeability or the use of cell line permeability studies (Caco2)
  2. To measure in vivo metabolism as a measure of drug stability in tissues or serum as well as to determine benchtop stability or other physical characteristics of a drug.

Percentage Of Time 10

Job Duty Category Analytical Analysis of Xenobiotics in Biological Matrices

Duty/Responsibility

  1. To measure drugs for stability and/or PK studies. This is done by using liquid chromatography (LC) coupled to tandem mass spectrometry (LC/MS) or by LC coupled to UV/Vis or fluorescence analysis. This usually involves sample preparation through the use of liquid-liquid extraction or SPE prior to analysis.
  2. This is the basis of drug measurement and is how they are quantitated.

Percentage Of Time 20

Job Duty Category Biochemical Assays of Cellular Metabolites or Xenobiotics

Duty/Responsibility

  1. This is a catch all for other assays to measure cellular components associated with drug metabolism or toxicity such as glutathione or P450 enzymes. This also includes ELISA assays for xenobiotics that cannot be measured using standard LC analysis and require immunoassays for analysis.
  2. These experiments are more based on determining mechanisms of drug activity and can be carried out in animal tissues or cell culture.

Percentage Of Time 10

Job Duty Category Planning Experiments and Developing Protocols and Budgets for Studies

Duty/Responsibility

  1. This involves review of the scientific literature to determine likely approaches and to consult with colleagues in the planning of studies including animal numbers, doses, timing, appropriate vehicles and endpoints. This may include consultation with pathologists and other collaborators.
  2. This is critical to studies involving novel compounds as well as to consult with investigators using the SR so that they know what the cost and timing of studies will be. The SR works in collaboration with investigators and thus this individual will serve as a conduit for information.

Percentage Of Time 20

Job Duty Category Data Analysis Calculations, Modeling and Preparation

Duty/Responsibility

  1. Generated data will be analyzed and fit to standard curves and determined if it fits the desired accuracy and precision for acceptance. This data is then reviewed for completeness and then appropriate modeling applied to complete the data and present to the investigator. This is done using spreadsheets and potentially specialized modeling software such as Phoenix WinNonLin or “R” based programs. This may also involve discussion, review of literature and iterations with colleagues.
  2. The DDDSR serves as a Shared Resource/Core Service and part of the service that we provide is complete data analysis with appropriate modeling, interpretation and presentation.

Percentage Of Time 20

Job Duty Category Preparation of Quotes and Billing of Users

Duty/Responsibility

  1. Once a study is planned and animal/sample numbers are determined a quote can be provided to a potential SR user utilizing the current price structure of the SR. This is done by completing a quote in Word, Excel or just composing an E-mail based on the preference of the user as well as the employee. Specialty quotes may involve consultation with colleagues and determining time required to carry out a specific task requested. Billing is usually done monthly or bi-monthly depending on volume and is prepared and communicated to the user. This may also involve some consultation with the payee institution/department to determine how this is going to be paid.
  2. As an SR, quotes and billing are critical to our function.

Percentage Of Time 10

Special Instructions to Applicants

Interested applicants must submit 1) a cover letter that addresses the minimum and preferred qualifications (include your experience and comfort level working with rodents), 2) a resume, and 3) the names of three references along with their contact information. References will not be contacted without prior notification of candidates.

Applications will be accepted until the position is filled but for full consideration, please submit application materials by 11:59 pm (MT) August 30, 2020, to receive full consideration.

Conditions of Employment Pre-employment Criminal Background Check (required for new hires)

Search Contact Cheryl Webb, ClinSciHR@colostate.edu

EEO Statement

Colorado State University is committed to providing an environment that is free from discrimination and harassment based on race, age, creed, color, religion, national origin or ancestry, sex, gender, disability, veteran status, genetic information, sexual orientation, gender identity or expression, or pregnancy and will not discharge or in any other manner discriminate against employees or applicants because they have inquired about, discussed, or disclosed their own pay or the pay of another employee or applicant. Colorado State University is an equal opportunity/equal access/affirmative action employer fully committed to achieving a diverse workforce and complies with all Federal and Colorado State laws, regulations, and executive orders regarding non-discrimination and affirmative action. The Office of Equal Opportunity is located in 101 Student Services.

The Title IX Coordinator is the Vice President for Equity, Equal Opportunity, and Title IX, 123 Student Services Building, Fort Collins, CO. 80523, (970) 491-1715.

The Section 504 and ADA Coordinator is the Vice President for Equity, Equal Opportunity, and Title IX, 101 Student Services Building, Fort Collins, CO 80523-0160, (970) 491-5836.

Background Check Policy Statement

Colorado State University strives to provide a safe study, work, and living environment for its faculty, staff, volunteers and students. To support this environment and comply with applicable laws and regulations, CSU conducts background checks. The type of background check conducted varies by position and can include, but is not limited to, criminal history, sex offender registry, motor vehicle history, financial history, and/or education verification. Background checks will also be conducted when required by law or contract and when, in the discretion of the University, it is reasonable and prudent to do so.

References Requested

Minimum Requested 3

Maximum Requested 3

Supplemental Questions

Required fields are indicated with an asterisk (*).

Applicant Documents

Required Documents

  • Cover Letter

  • Resume

Optional Documents

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