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Pfizer Senior Principal Scientist, Computational Chemistry in Boulder, Colorado

Array BioPharma (recently acquired by Pfizer) is a biopharmaceutical company headquartered in Boulder, CO with locations in Cambridge, MA and Morrisville, NC. We are focused on the discovery, development, and commercialization of targeted small molecule drugs to treat patients afflicted with cancer. Array recently received approval and launched BRAFTOVI (encorafenib) and MEKTOVI (binimetinib) for the treatment of patients with BRAF mutated melanoma. These products have also been granted Breakthrough Therapy Designation by the FDA for BRAF mutated CRC.

The Array Discovery team (WRD) and this role is based in Boulder, Colorado. This role will report into Jim Blake, Senior Research Fellow, on the Array Discovery team.

With more than 300 days a year of sunshine, Boulder is a paradise in the West! Hikers, bikers, foodies, beer enthusiasts, art and theater lovers, and more feel right at home here. Visit to discover what we love about Boulder. Many Array colleagues live just outside of Boulder in Longmont, Westminster, Lafayette, and other surrounding communities and have commutes of only 15 to 20 minutes.


We are seeking a Sr Principal Scientist, Computational Chemist to join our research group. The ideal candidate will have a proven track record of using computational insights to guide medicinal chemistry projects in a pharmaceutical environment. This position will develop into a leadership role within the computational chemistry group.


The successful candidate will

  • Be part of multidisciplinary teams working on the design and evaluation of new disease targets and analogues for key medicinal chemistry projects

  • Identifies and develops scientific strategies to support goals .

  • Promote and evaluate new computational techniques and technologies for drug discovery

  • Assist the medicinal chemistry teams with prioritization and compound design

  • Works independently (under minimal supervision) and makes decisions that require developing new options to solve complex problems.

  • Represent the computational chemistry group to management and internal collaborators

  • Provides formal/informal mentoring

  • As a member of multidisciplinary teams, you will have the opportunity to influence lead optimization and lead identification efforts throughout the organization


  • Ph.D. Computational Chemistry

  • 8+ years' post graduate experience in the pharmaceutical industry applying various methods of computer modeling to drug discovery projects

  • Skilled in applying state-of-the-art methods and tools for structure-based drug design, in silico screening, QSAR, and pharmacophore development

  • Must be self-motivated, have exceptional communication skills, and have a strong grasp of bio-organic and physical chemistry concepts

  • Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.


  • Experience with programming languages that are used in scientific applications is a plus

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.


Other Job Details:

  • Eligible for Relocation Package

  • Eligible for Employee Referral Bonus

Other Job Details:

  • This job is (Pfizer/Hospira) (Exempt/Non-exempt) (US/PR) Grade : 13

  • US/PR colleagues who are issued an Incident Final Warning (IFW) disciplinary action are not eligible to post and compete for a position for a period of 12-months from the date an IFW is issued.

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.

Research and Development