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Pfizer Inc. Principal Scientist, Enzymology in Boulder, Colorado

Pfizer-Boulder (formerly Array BioPharma) is focused on the discovery,development and commercialization of targeted small molecule drugs to treatpatients afflicted with cancer.We recently received approval and launchedBRAFTOVI (encorafenib) and MEKTOVI (binimetinib) for the treatment ofpatients with BRAF mutated melanoma. These products have also been grantedBreakthrough Therapy Designation by the FDA for BRAF mutated CRC.With more than 300 days a year of sunshine, Boulder-Colorado is a paradisein the West!Hikers, bikers, foodies, beer enthusiasts, art andtheater lovers, and more feel right at home here.Visit to discover what welove about Boulder.ROLE SUMMARYWe seek an exceptional scientist with demonstrated experience employing steadystate and/or biophysical techniques to characterize the interaction of smallmolecule inhibitors with their protein targets. This person will beresponsible for assay development, screening, lead characterization andlead optimization in a collaborative team environment, working closely withstructural biologists, protein chemists, computational and medicinalchemists. The candidate will take a functional leadership role on theseproject teams in a fast-paced drug discovery environment. Additionally, thecandidate will mentor other members of the group in mechanistic enzymology.ROLE RESPONSIBILITIESIndependently lead enzymology effort on project team(s) with assaydevelopment, HTS, assay support and mechanism of action studiesDocument and provide regular, written and/or verbal reports ofexperimental findings as well as offering strategic guidance to the projectteam(s)Mentor more junior Enzymology Group members and other Biology Departmentmembers in mechanistic enzymologySolve complex problems in mechanistic enzymology related to drug discoveryPresent at group meetings, global project team meetings, and site meetingsCollaborate with medicinal chemists, computational chemists, structuralbiologists, and cell biologists to pursue the most promising small moleculecompounds through candidate identification and selectionMay supervise research associates and/or scientistsBASIC QUALIFICATIONSPh.D. in biochemistry or related field with 5+ years of postdoctoralexperience and relevant industry experienceAdvanced knowledge of mechanistic enzymology and biophysical technologiessupported by peer-reviewed publicationsDemonstrated expertise determining enzyme mechanisms and inhibitor MOA'susing steady-state kinetics and related technologiesAbility to manage an independent research program with no supervisionincluding designing, planning, executing, interpreting and documentingexperimentsStrong organizational and interpersonal skillsAbility to work well with team members across functional areasSelf-motivation with a desire to learnDemonstrated scientific excellence with attention to detailAbility to organize and communicate complex data sets in a clear and concisemanner to key stakeholders from diverse backgroundsAbility to represent discovery teams and communicate goals/deliverables tosenior management and/or governance committeesPREFERRED QUALIFICATIONSSmall molecule drug discovery experience in an industrial settingExperience in laboratory robotics and high throughput screeningExperience with general biochemical and kinetic-based assay technologies(e.g., FI, FP, TR-FRET, LanthaScreen, AlphaScreen, luminescence)Experience in biophysical techniques for characterizing interactions betweenproteins and ligandsExperience in mentoring and/or leading Ph.D. level and non-Ph.D. levelscientistsExperience in curve-fitting, statistics and assay optimization (DOE)Proficiency with Microsoft Office and associated applications (e.g.,XLfit), Spotfire, Design-ExpertOTHER JOB DETAILSEligible for Relocation PackageEligible for Employee Referral Bonus#LI-PFESunshine ActPfizer reports payments and other transfers of value to health care providersas required by federal and state transparency laws and implementingregulations. These laws and